May River Manor in Bluffton is a luxurious boutique escape with a truly inspiring backstory. The property began life as an nine-bedroom center supporting women in need before being donated to the University of South Carolina Beaufort. In 2022 it underwent a thoughtful transformation into a six-suite manor that honors its history while offering modern elegance. Spread across five and a half acres, the manor blends gentle Lowcountry charm with the refined comforts of a luxury retreat.

Each guest suite, with plush linens, spa‑quality robes, and ensuite bathrooms make every stay like a pampered getaway. Mornings begin with a gourmet breakfast and afternoons bring complimentary refreshments by the pool. The manor’s front and rear porches offer perfect spots to sip coffee or toast the sunset. Close enough to Bluffton’s historic district yet tucked into its own quiet haven, this is the ideal base for your Lowcountry adventure.